Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 3/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.39 |
| ▸ | FLT3 | P36888 | 2/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.38 |
| ▸ | CDK9 | P50750 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 4/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2920098 | 0.80 | CYP1A2 (0.52) | LMNACYP1A2CYP3A4CLK4CYP2C19 | |
| SCHEMBL2920237 | 0.77 | PDGFRB (0.65) | KITPDGFRBFLT3PDGFRA | |
| SCHEMBL27734124 | 0.72 | FLT3 (0.67) | KITPDGFRBFLT3 | |
| Piperazine SCHEMBL27734165 | 0.70 | TYR (0.42) | LMNACYP1A2CYP3A4CYP2C19HTR2A | |
| SCHEMBL28775244 | 0.66 | FLT3 (0.66) | KITPDGFRBFLT3 | |
| SCHEMBL2923601 | 0.66 | CYP1A2 (0.55) | LMNACYP1A2CYP3A4CLK4CYP2C19 | |
| SCHEMBL19695809 | 0.66 | HTT (0.51) | LMNACYP1A2CYP3A4CLK4CYP2C19 | |
| SCHEMBL2924702 | 0.65 | PDGFRB (0.56) | LMNAKITPDGFRBFLT3PDGFRA | |
| SCHEMBL2086181 | 0.64 | TYR (0.52) | LMNAMAPK1 | |
| SCHEMBL19695793 | 0.64 | HTT (0.49) | LMNACYP1A2CYP3A4CLK4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207667-B1 | USEFUL FOR THE TREATMENT OF CELL-PROLIFERATIVE DISEASES SUCH AS ARTERIOSCLEROSIS, VASCULAR REOBSTRUCTION, CANCER AND GLOMERULOSCLEROSIS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |