Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 9/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7955468 | 1.00 | PDE4A (0.51) | PDE4AKCNH2PDE4BPDE4CPDE4D | |
| SCHEMBL7951781 | 0.91 | PDE4A (0.42) | PDE4AKCNH2PDE4BPDE4CPDE4D | |
| SCHEMBL7951784 | 0.91 | PDE4A (0.42) | PDE4AKCNH2PDE4BPDE4CPDE4D | |
| SCHEMBL7960486 | 0.88 | ELANE (0.42) | PDE4AKCNH2ELANES1PR1S1PR3 | |
| SCHEMBL7946333 | 0.88 | ELANE (0.42) | PDE4AKCNH2ELANES1PR1S1PR3 | |
| SCHEMBL7951678 | 0.88 | CNR1 (0.43) | PDE4AKCNH2PDE4BPDE4CPDE4D | |
| SCHEMBL7951680 | 0.88 | CNR1 (0.43) | PDE4AKCNH2PDE4BPDE4CPDE4D | |
| SCHEMBL7953708 | 0.87 | PDE4A (0.38) | PDE4AKCNH2PDE4BPDE4CPDE4D | |
| SCHEMBL7963038 | 0.87 | PDE4A (0.38) | PDE4AKCNH2PDE4BPDE4CPDE4D | |
| SCHEMBL7951623 | 0.86 | KCNH2 (0.37) | PDE4AKCNH2PDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6331548-B1 | PREVENTION OR TREATMENT OF CYTOKINE RELATED DISEASES | SUNTORY LIMITED (JP) | 2001-12-18 | — | — | US | disclosed |
| EP-0978516-A1 | 1-CYCLOALKYL-1,8-NAPHTHYRIDIN-4-ONE DERIVATIVES WITH PHOSPHODIESTERASE IV INHIBITORY ACTIVITY | SUNTORY LIMITED (JP) | 2000-02-09 | — | — | EP | disclosed |