SCHEMBL7961981

SCHEMBL7961981

COc1cc(C(=O)N(C)c2ccc(C)cc2OCCCCCC(=O)N2CCN(C)CC2)ccc1C(=O)Nc1cccc2[nH]c(CCN3CCN(C)CC3)nc12

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAP3K7 O43318 2/20 0.35
ABCB1 P08183 2/20 0.34
ABCG2 Q9UNQ0 2/20 0.34
LCK P06239 1/20 0.34
EGFR P00533 1/20 0.34
KDR P35968 1/20 0.34
ADRA1D P25100 3/20 0.34
ADRA1A P35348 3/20 0.34
ADRA1B P35368 3/20 0.34
AVPR2 P30518 2/20 0.33
AVPR1A P37288 2/20 0.33
AVPR1B P47901 1/20 0.33
HDAC3 O15379 1/20 0.33
BRD4 O60885 1/20 0.33
HDAC4 P56524 1/20 0.33
HDAC1 Q13547 1/20 0.33
HDAC7 Q8WUI4 1/20 0.33
HDAC2 Q92769 1/20 0.33
HDAC10 Q969S8 1/20 0.33
HDAC11 Q96DB2 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7962051 0.99 MAP3K7 (0.35) MAP3K7ABCB1ABCG2LCKEGFR
SCHEMBL7967811 0.95 AVPR2 (0.34) MAP3K7ABCB1ABCG2AVPR2AVPR1A
SCHEMBL7430655 0.95 MAP3K7 (0.34) MAP3K7EGFRKDRADRA1DADRA1A
Hydrochloric Acid SCHEMBL7964462 0.94 MAP3K7 (0.34) MAP3K7EGFRKDRADRA1DADRA1A
SCHEMBL7972295 0.94 AVPR2 (0.33) MAP3K7ABCB1ABCG2AVPR2AVPR1A
Hydrochloric Acid SCHEMBL7968188 0.94 AVPR2 (0.33) MAP3K7ABCB1ABCG2AVPR2AVPR1A
SCHEMBL7962048 0.94 AVPR2 (0.33) MAP3K7ABCB1ABCG2LCKAVPR2
Hydrochloric Acid SCHEMBL7966255 0.94 AVPR2 (0.33) MAP3K7ABCB1ABCG2AVPR2AVPR1A
Hydrochloric Acid SCHEMBL7476210 0.94 AVPR2 (0.33) MAP3K7ABCB1ABCG2LCKAVPR2
SCHEMBL7962166 0.94 AVPR2 (0.35) MAP3K7AVPR2AVPR1AAVPR1BHDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6207693-B1 Benzamide derivatives having a vasopressin antagonistic activity FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-03-27 US disclosed