SCHEMBL7962010

SCHEMBL7962010

Cc1cccc2c1nc(COc1ccc(Cl)cc1)n2CCCc1ccccc1

nearest known ligand 0.77

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
NPY1R P25929 19/20 0.77
TP53 P04637 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7689734 0.90 NPY1R (0.67) NPY1R
SCHEMBL7693276 0.90 NPY1R (0.81) NPY1R
SCHEMBL7963411 0.89 NPY1R (0.64) NPY1R
SCHEMBL7685664 0.88 NPY1R (1.00) NPY1R
SCHEMBL7692424 0.87 NPY1R (0.65) NPY1R
SCHEMBL7688977 0.86 NPY1R (0.69) NPY1RTP53
SCHEMBL7690351 0.86 NPY1R (0.69) NPY1RTP53
SCHEMBL7685814 0.86 NPY1R (0.69) NPY1RTP53
SCHEMBL7690548 0.85 NPY1R (0.95) NPY1R
SCHEMBL7688924 0.85 NPY1R (0.68) NPY1RTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6255494-B1 SUBSTITUTED BENZIMIDAZOLES USEFUL IN TREATING OR PREVENTING CONDITIONS ASSOCIATED WITH EXCESS OF NEUROPEPTIDE Y (AROUND ARTERIES IN HEART, RESPIRATORY TRACT, GASTROINTESTINAL TRACT AND GENITOURINARY TRACT); ETIOLOGY OF PSYCHIATRIC DISORDERS ELI LILLY AND COMPANY 2001-07-03 US disclosed