Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 4/20 | 0.38 |
| ▸ | AVPR1A | P37288 | 4/20 | 0.38 |
| ▸ | AVPR1B | P47901 | 4/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.36 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7966750 | 0.87 | AVPR2 (0.38) | AVPR2AVPR1AAVPR1BIRAK4P2RY12 | |
| Hydrochloric Acid SCHEMBL7973715 | 0.86 | AVPR2 (0.37) | AVPR2AVPR1AAVPR1BIRAK4P2RY12 | |
| SCHEMBL7964976 | 0.85 | AVPR2 (0.39) | AVPR2AVPR1AAVPR1BIRAK4 | |
| SCHEMBL7342173 | 0.85 | AVPR2 (0.43) | AVPR2AVPR1AAVPR1B | |
| Hydrochloric Acid SCHEMBL7965268 | 0.84 | AVPR2 (0.39) | AVPR2AVPR1AAVPR1BIRAK4 | |
| SCHEMBL7338105 | 0.84 | AVPR2 (0.42) | AVPR2AVPR1AAVPR1B | |
| SCHEMBL7342320 | 0.84 | AVPR2 (0.41) | AVPR2AVPR1AAVPR1BHDAC1HDAC6 | |
| SCHEMBL7969301 | 0.83 | AVPR2 (0.40) | AVPR2AVPR1AAVPR1BIRAK4 | |
| SCHEMBL7964063 | 0.83 | AVPR2 (0.40) | AVPR2AVPR1AAVPR1BIRAK4 | |
| SCHEMBL7969502 | 0.83 | AVPR2 (0.35) | AVPR2AVPR1AAVPR1BIRAK4P2RY12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316482-B1 | FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |
| US-6207693-B1 | Benzamide derivatives having a vasopressin antagonistic activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |