Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 17/20 | 0.66 |
| ▸ | PDE6C | P51160 | 3/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | PDE1A | P54750 | 2/20 | 0.66 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.66 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.66 |
| ▸ | HPGD | P15428 | 1/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.60 |
| ▸ | PDE2A | O00408 | 1/20 | 0.60 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.60 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.60 |
| ▸ | PDE6D | O43924 | 1/20 | 0.60 |
| ▸ | PDE8A | O60658 | 1/20 | 0.60 |
| ▸ | PDE9A | O76083 | 1/20 | 0.60 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7962779 | 1.00 | PDE5A (0.66) | PDE5APDE6CKMT2APDE1APDE1B | |
| SCHEMBL15996180 | 0.88 | PDE5A (0.73) | PDE5APDE6CKMT2APDE1APDE1B | |
| SCHEMBL7964970 | 0.86 | PDE5A (0.71) | PDE5APDE6CKMT2APDE1APDE1B | |
| SCHEMBL7964973 | 0.86 | PDE5A (0.71) | PDE5APDE6CKMT2APDE1APDE1B | |
| SCHEMBL15995585 | 0.85 | PDE5A (0.71) | PDE5APDE6CKMT2APDE1APDE1B | |
| SCHEMBL7950897 | 0.85 | PDE5A (0.66) | PDE5APDE6CKMT2APDE1APDE1B | |
| SCHEMBL7950902 | 0.85 | PDE5A (0.66) | PDE5APDE6CKMT2APDE1APDE1B | |
| SCHEMBL7959696 | 0.84 | PDE5A (0.68) | PDE5APDE6CKMT2APDE1APDE1B | |
| SCHEMBL7959701 | 0.84 | PDE5A (0.68) | PDE5APDE6CKMT2APDE1APDE1B | |
| SCHEMBL18715171 | 0.82 | PDE5A (0.75) | PDE5APDE6CKMT2APDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6200980-B1 | ADMINISTERING PHENYL PURINONE COMPOUND FOR TREATING PRECANCEROUS LEISONS | CELL PATHWAYS, INC. | 2001-03-13 | — | — | US | disclosed |
| EP-0526004-B1 | Pyrazolopyrimidinone antianginal agents | PFIZER LTD (GB) | 1997-10-08 | — | — | EP | disclosed |
| US-5426107-A | Treatment of cardiovascular disorders, asthma, allergies | PFIZER INC. (US) | 1995-06-20 | — | — | US | disclosed |
| EP-0526004-A1 | Pyrazolopyrimidinone antianginal agents | Pfizer Limited (GB) | 1993-02-03 | — | — | EP | disclosed |