Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 13/20 | 0.73 |
| ▸ | EGFR | P00533 | 11/20 | 0.73 |
| ▸ | RET | P07949 | 6/20 | 0.73 |
| ▸ | KIF5B | P33176 | 6/20 | 0.73 |
| ▸ | FLT1 | P17948 | 5/20 | 0.70 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.70 |
| ▸ | FLT4 | P35916 | 3/20 | 0.70 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.69 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.69 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.69 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.60 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | GAK | O14976 | 1/20 | 0.60 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.60 |
| ▸ | ABL1 | P00519 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CDK1 | P06493 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | FBP1 | P09467 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7215101 | 0.99 | KDR (0.72) | KDREGFRRETKIF5BFLT1 | |
| SCHEMBL2138034 | 0.90 | KDR (0.61) | KDREGFRRETKIF5BFLT1 | |
| SCHEMBL2137462 | 0.88 | EGFR (0.64) | KDREGFRRETKIF5BFLT1 | |
| SCHEMBL31554485 | 0.87 | EGFR (0.64) | KDREGFRRETKIF5BFLT1 | |
| SCHEMBL5864737 | 0.86 | EGFR (0.78) | KDREGFRRETKIF5BFLT1 | |
| Hydrochloric Acid SCHEMBL7209985 | 0.86 | KDR (0.70) | KDREGFRRETKIF5BFLT1 | |
| SCHEMBL5864525 | 0.85 | KDR (1.00) | KDREGFRRETKIF5BFLT1 | |
| SCHEMBL5864655 | 0.84 | KDR (0.63) | KDREGFRRETKIF5BFLT1 | |
| SCHEMBL2138023 | 0.84 | KDR (1.00) | KDREGFRRETKIF5BFLT1 | |
| Hydrochloric Acid SCHEMBL7864775 | 0.84 | KDR (0.98) | KDREGFRRETKIF5BFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880508-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | claimed |
| WO-1997030035-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ZENECA LIMITED (GB) | 1997-08-21 | — | — | WO | claimed |
| US-6184225-B1 | ENDOTHELIAL GROWTH FACTOR INHIBITORS, ANGIOGENESIS INHIBITORS | ZENECA LIMITED (GB) | 2001-02-06 | — | — | US | disclosed |
| EP-0880508-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997030035-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ZENECA LIMITED (GB) | 1997-08-21 | — | — | WO | disclosed |