Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7568330 | 0.99 | MEN1 (0.36) | MEN1KMT2ARAB9ACNR2MAPT | |
| SCHEMBL7478105 | 0.92 | IRAK4 (0.37) | MEN1KMT2ARAB9ACNR2MAPT | |
| Hydrochloric Acid SCHEMBL7968769 | 0.91 | IRAK4 (0.37) | MEN1KMT2ARAB9ACNR2MAPT | |
| SCHEMBL7964830 | 0.91 | IRAK4 (0.37) | MEN1KMT2ARAB9ACNR2MAPT | |
| Hydrochloric Acid SCHEMBL7610476 | 0.91 | IRAK4 (0.36) | MEN1KMT2ARAB9ACNR2MAPT | |
| SCHEMBL7480849 | 0.86 | AVPR2 (0.35) | MEN1KMT2ALMNAHDAC3BRD4 | |
| Hydrochloric Acid SCHEMBL7481449 | 0.86 | AVPR2 (0.35) | LMNAHDAC3BRD4HDAC4HDAC1 | |
| Dimethylamine SCHEMBL7972125 | 0.85 | AVPR2 (0.35) | MEN1KMT2ALMNAHDAC3BRD4 | |
| SCHEMBL7564594 | 0.85 | RXFP1 (0.37) | MEN1KMT2ARAB9AMAPTLMNA | |
| Dimethylamine SCHEMBL7975691 | 0.85 | AVPR2 (0.34) | LMNAHDAC3BRD4HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316482-B1 | FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |
| US-6207693-B1 | Benzamide derivatives having a vasopressin antagonistic activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |