Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 5/20 | 0.39 |
| ▸ | AVPR1A | P37288 | 5/20 | 0.39 |
| ▸ | AVPR1B | P47901 | 4/20 | 0.39 |
| ▸ | MAP3K7 | O43318 | 4/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7595093 | 0.99 | AVPR2 (0.38) | AVPR2AVPR1AAVPR1BMAP3K7IRAK4 | |
| Hydrochloric Acid SCHEMBL7595084 | 0.92 | MAP3K7 (0.37) | AVPR2AVPR1AAVPR1BMAP3K7IRAK4 | |
| SCHEMBL7962290 | 0.91 | MAP3K7 (0.44) | AVPR2AVPR1AAVPR1BMAP3K7IRAK4 | |
| SCHEMBL7954262 | 0.90 | AVPR2 (0.39) | AVPR2AVPR1AAVPR1BMAP3K7IRAK4 | |
| Hydrochloric Acid SCHEMBL7480961 | 0.90 | MAP3K7 (0.44) | AVPR2AVPR1AAVPR1BMAP3K7IRAK4 | |
| SCHEMBL7474294 | 0.90 | AVPR2 (0.38) | AVPR2AVPR1AAVPR1BMAP3K7IRAK4 | |
| SCHEMBL7473089 | 0.90 | AVPR2 (0.38) | AVPR2AVPR1AAVPR1BMAP3K7IRAK4 | |
| Hydrochloric Acid SCHEMBL7967198 | 0.90 | AVPR2 (0.38) | AVPR2AVPR1AAVPR1BMAP3K7IRAK4 | |
| SCHEMBL7484507 | 0.89 | AVPR2 (0.38) | AVPR2AVPR1AAVPR1BMAP3K7IRAK4 | |
| SCHEMBL7962259 | 0.89 | AVPR2 (0.38) | AVPR2AVPR1AAVPR1BMAP3K7IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316482-B1 | FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |
| US-6207693-B1 | Benzamide derivatives having a vasopressin antagonistic activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |