Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XIAP | P98170 | 1/20 | 0.48 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 9/20 | 0.45 |
| ▸ | CDK4 | P11802 | 5/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.40 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL701624 | 0.90 | XIAP (0.49) | XIAPBIRC2CDK2CDK4CCNE1 | |
| SCHEMBL10252168 | 0.90 | XIAP (0.47) | XIAPBIRC2CDK2CDK4CCNE1 | |
| SCHEMBL10252455 | 0.86 | CDK2 (0.45) | XIAPBIRC2CDK2CDK4CCNE1 | |
| SCHEMBL7975067 | 0.82 | CDK2 (0.66) | CDK2CDK4CCNE1SYKALDH1A1 | |
| SCHEMBL7978508 | 0.82 | CDK2 (0.51) | XIAPBIRC2CDK2CDK4CCNE1 | |
| SCHEMBL700084 | 0.81 | XIAP (0.45) | XIAPBIRC2CDK2CDK4CCNE1 | |
| SCHEMBL7975631 | 0.81 | CDK2 (0.44) | XIAPBIRC2CDK2CDK4CCNE1 | |
| SCHEMBL7975623 | 0.79 | CDK2 (0.43) | XIAPBIRC2CDK2CDK4CCNE1 | |
| SCHEMBL700972 | 0.78 | HDAC6 (0.47) | XIAPBIRC2CDK2CDK4CCNE1 | |
| SCHEMBL7978465 | 0.78 | CDK2 (0.47) | XIAPBIRC2CDK2CDK4CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010009155-A2 | FUSED HETEROCYCLYC INHIBITOR COMPOUNDS | GILEAD COLORADO, INC. (US) | 2010-01-21 | — | — | WO | disclosed |