Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 15/20 | 0.85 |
| ▸ | JAK3 | P52333 | 1/20 | 0.85 |
| ▸ | JAK1 | P23458 | 6/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2244635 | 0.92 | JAK3 (1.00) | JAK2JAK3JAK1 | |
| SCHEMBL2238774 | 0.92 | JAK2 (1.00) | JAK2JAK3JAK1 | |
| SCHEMBL2238480 | 0.92 | JAK2 (0.80) | JAK2JAK3JAK1 | |
| SCHEMBL2239300 | 0.92 | JAK2 (0.81) | JAK2JAK3JAK1 | |
| SCHEMBL2236737 | 0.89 | JAK2 (0.80) | JAK2JAK3JAK1 | |
| SCHEMBL13031660 | 0.87 | JAK3 (0.74) | JAK2JAK3JAK1 | |
| SCHEMBL2241461 | 0.87 | JAK2 (0.80) | JAK2JAK3JAK1 | |
| SCHEMBL7963258 | 0.87 | JAK1 (0.80) | JAK2JAK3JAK1 | |
| SCHEMBL2243535 | 0.86 | JAK2 (0.78) | JAK2JAK3JAK1 | |
| SCHEMBL2238681 | 0.86 | JAK2 (0.83) | JAK2JAK3JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010010190-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |