Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 5/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7967361 | 0.95 | BRD4 (0.36) | PARP1BRD4 | |
| SCHEMBL7955465 | 0.95 | BRD4 (0.36) | PARP1BRD4TP53 | |
| SCHEMBL7962108 | 0.94 | PARP1 (0.36) | PARP1BRD4 | |
| SCHEMBL7961971 | 0.94 | AVPR2 (0.37) | PDE3BPDE3APARP1BRD4 | |
| SCHEMBL7482373 | 0.91 | BRD4 (0.34) | PARP1BRD4MAPT | |
| SCHEMBL7483103 | 0.91 | BRD4 (0.36) | PARP1BRD4MAPT | |
| SCHEMBL7965806 | 0.90 | BRD4 (0.34) | PARP1BRD4MAPT | |
| SCHEMBL7479422 | 0.90 | BRD4 (0.35) | PARP1BRD4MAPT | |
| SCHEMBL7964884 | 0.89 | BRD4 (0.35) | PARP1BRD4 | |
| SCHEMBL7474276 | 0.89 | BRD4 (0.34) | PARP1BRD4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316482-B1 | FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |
| US-6207693-B1 | Benzamide derivatives having a vasopressin antagonistic activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |