Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.67 |
| ▸ | GAA | P10253 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.54 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | P2RY1 | P47900 | 5/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 2/20 | 0.48 |
| ▸ | BRAF | P15056 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29497315 | 0.93 | MAPT (0.65) | MAPTGAARAB9AKDM4EMAPK1 | |
| SCHEMBL29732862 | 0.93 | MAPT (0.65) | MAPTGAARAB9AKDM4EMAPK1 | |
| SCHEMBL54805 | 0.93 | MAPT (0.65) | MAPTGAARAB9AKDM4EMAPK1 | |
| SCHEMBL7612444 | 0.93 | MAPT (0.67) | MAPTGAARAB9AKDM4EMAPK1 | |
| SCHEMBL7605482 | 0.92 | MAPT (0.67) | MAPTGAARAB9AKDM4EMAPK1 | |
| SCHEMBL7953536 | 0.92 | MAPT (0.69) | MAPTGAARAB9AKDM4EMAPK1 | |
| SCHEMBL7953393 | 0.88 | MAPT (0.64) | MAPTGAARAB9AKDM4EMAPK1 | |
| SCHEMBL3841693 | 0.87 | MAPT (0.75) | MAPTGAARAB9AKDM4EMAPK1 | |
| SCHEMBL27576744 | 0.86 | MAPT (0.54) | MAPTGAARAB9AKDM4EL3MBTL1 | |
| SCHEMBL8065139 | 0.84 | MAPT (0.72) | MAPTGAARAB9AKDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6271372-B1 | REACTING HETEROAROMATIC HALOGEN COMPOUNDS WITH CARBON MONOXIDE AND AROMATIC AMINES IN THE PRESENCE OF A COMPLEX OF PALLADIUM WITH A TRIPHENYLPHOSPHINE AND A BASE OTHER THAN AN AMINE. | LONZA AG (CH) | 2001-08-07 | — | — | US | disclosed |
| US-5900484-A | FROM HETEROAROMATIC HALOGEN COMPOUNDS AND AROMATIC AMINES AND CARBON MONOXIDE WITH PALLADIUM PHOSPHINE COMPLEX | LONZA AG (CH) | 1999-05-04 | — | — | US | disclosed |