Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 15/20 | 0.55 |
| ▸ | PDE4A | P27815 | 2/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | GUSB | P08236 | 1/20 | 0.48 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.44 |
| ▸ | PDE1A | P54750 | 2/20 | 0.44 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.44 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | PDE2A | O00408 | 1/20 | 0.44 |
| ▸ | PDE6D | O43924 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfuric Acid SCHEMBL7950944 | 0.94 | PDE5A (0.50) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7029661 | 0.84 | PDE5A (0.62) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7959294 | 0.82 | PDE5A (0.56) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7959688 | 0.81 | FGFR1 (0.60) | PDE5AMEN1ALDH1A1MAPTHPGD | |
| Sulfuric Acid SCHEMBL7959122 | 0.81 | GUSB (0.58) | PDE5AMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL7959395 | 0.80 | MEN1 (0.49) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7951339 | 0.79 | PDE5A (0.56) | PDE5APDE4APDE4BPDE4CPDE4D | |
| Sulfuric Acid SCHEMBL7718120 | 0.79 | PDE5A (0.56) | PDE5APDE4APDE4BPDE4CPDE4D | |
| Sulfuric Acid SCHEMBL7960505 | 0.78 | PDE5A (0.52) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2564939 | 0.78 | GUSB (0.60) | PDE5AMEN1ALDH1A1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6200980-B1 | ADMINISTERING PHENYL PURINONE COMPOUND FOR TREATING PRECANCEROUS LEISONS | CELL PATHWAYS, INC. | 2001-03-13 | — | — | US | disclosed |
| EP-0293063-B1 | 2-PHENYLPURINONE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, AND THEIR USE AS WELL AS INTERMEDIATES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1992-03-18 | — | — | EP | disclosed |
| US-4885301-A | Purinone derivatives which have bronchodilator, vasodilator and anti-allergic activities | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-12-05 | — | — | US | disclosed |
| EP-0293063-A1 | 2-Phenylpurinone derivatives, processes for their preparation, and their use as well as intermediates | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1988-11-30 | — | — | EP | disclosed |