Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A3 | P43003 | 2/20 | 0.45 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.45 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | TACR1 | P25103 | 3/20 | 0.43 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7965733 | 1.00 | SLC1A3 (0.45) | SLC1A3SLC1A2SLC1A1CYP2D6MEN1 | |
| SCHEMBL7965740 | 1.00 | SLC1A3 (0.45) | SLC1A3SLC1A2SLC1A1CYP2D6MEN1 | |
| SCHEMBL14195280 | 0.85 | SLC1A3 (0.45) | SLC1A3SLC1A2SLC1A1CYP2D6MEN1 | |
| SCHEMBL4099990 | 0.85 | ANPEP (0.46) | SLC1A3SLC1A2SLC1A1CYP2D6MEN1 | |
| SCHEMBL5679211 | 0.85 | ANPEP (0.46) | SLC1A3SLC1A2SLC1A1CYP2D6MEN1 | |
| SCHEMBL17833682 | 0.85 | ANPEP (0.46) | SLC1A3SLC1A2SLC1A1CYP2D6MEN1 | |
| SCHEMBL20194387 | 0.85 | SLC1A3 (0.45) | SLC1A3SLC1A2SLC1A1CYP2D6MEN1 | |
| SCHEMBL13696735 | 0.85 | SLC1A3 (0.45) | SLC1A3SLC1A2SLC1A1CYP2D6MEN1 | |
| SCHEMBL29250597 | 0.85 | SLC1A3 (0.45) | SLC1A3SLC1A2SLC1A1CYP2D6MEN1 | |
| Hydrochloric Acid SCHEMBL5681286 | 0.84 | ANPEP (0.44) | SLC1A3SLC1A2SLC1A1CYP2D6MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6274715-B1 | SEMISYNTHETIC MACROLIDES, USEFUL IN BACTERIAL INFECTIONS TREATMENT AND PREVENTION, HAS LESS POTENTIAL FOR DEVELOPING RESISTANCE, IMPROVED OR MODIFIED PROFILES OF DESIRED GRAM-NEGATIVE ACTIVITY | ABBOTT LABORATORIES | 2001-08-14 | — | — | US | disclosed |
| EP-0961776-A1 | TRICYCLIC ERYTHROMYCIN DERIVATIVES | Abbott Laboratories (US) | 1999-12-08 | — | — | EP | disclosed |
| WO-1998030574-A1 | TRICYCLIC ERYTHROMYCIN DERIVATIVES | ABBOTT LABORATORIES (US) | 1998-07-16 | — | — | WO | disclosed |