Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 8/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | MME | P08473 | 1/20 | 0.39 |
| ▸ | ACE | P12821 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | TEK | Q02763 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7980204 | 1.00 | PTAFR (0.45) | PTAFRP2RX7GRIN1GRIN2BMME | |
| SCHEMBL7980157 | 0.90 | PTAFR (0.42) | PTAFRP2RX7POLBHPGDHTT | |
| SCHEMBL7978603 | 0.85 | PTAFR (0.44) | PTAFRP2RX7GRIN1GRIN2BPOLB | |
| SCHEMBL7979906 | 0.85 | PTAFR (0.44) | PTAFRP2RX7GRIN1GRIN2BPOLB | |
| Oxalic Acid SCHEMBL7966040 | 0.85 | PTAFR (0.45) | PTAFRP2RX7GRIN1GRIN2BMME | |
| Oxalic Acid SCHEMBL7980200 | 0.85 | PTAFR (0.45) | PTAFRP2RX7GRIN1GRIN2BMME | |
| SCHEMBL8481823 | 0.81 | PTAFR (0.44) | PTAFRP2RX7GRIN1GRIN2BMME | |
| SCHEMBL8483438 | 0.81 | PTAFR (0.44) | PTAFRP2RX7GRIN1GRIN2BMME | |
| SCHEMBL8481170 | 0.81 | PTAFR (0.44) | PTAFRP2RX7GRIN1GRIN2BMME | |
| SCHEMBL8476738 | 0.81 | PTAFR (0.42) | PTAFRP2RX7GRIN1GRIN2BSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6300352-B1 | FOR THERAPY OF ASTHMA | ASTRAZENECA AB (SE) | 2001-10-09 | — | — | US | disclosed |
| EP-0971892-A1 | NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Astra Pharmaceuticals Limited (GB) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998042670-A1 | NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ASTRA PHARMACEUTICALS LTD. (GB) | 1998-10-01 | — | — | WO | disclosed |