Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.66 |
| ▸ | FLT1 | P17948 | 6/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 2/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.47 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.44 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.44 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7966674 | 1.00 | EGFR (0.66) | EGFRFLT1PIK3CAPIK3CGKDR | |
| SCHEMBL7978781 | 0.91 | EGFR (0.78) | EGFRFLT1PIK3CAPIK3CGKDR | |
| SCHEMBL7978783 | 0.91 | EGFR (0.78) | EGFRFLT1PIK3CAPIK3CGKDR | |
| SCHEMBL7978623 | 0.87 | EGFR (0.60) | EGFRFLT1PIK3CAPIK3CGKDR | |
| SCHEMBL7978627 | 0.87 | EGFR (0.60) | EGFRFLT1PIK3CAPIK3CGKDR | |
| SCHEMBL7976662 | 0.87 | EGFR (0.62) | EGFRFLT1PIK3CAPIK3CGKDR | |
| SCHEMBL7976658 | 0.87 | EGFR (0.62) | EGFRFLT1PIK3CAPIK3CGKDR | |
| SCHEMBL7979943 | 0.85 | RET (0.60) | EGFRFLT1KDRRETERBB2 | |
| SCHEMBL7979945 | 0.85 | RET (0.60) | EGFRFLT1KDRRETERBB2 | |
| SCHEMBL5552543 | 0.84 | EGFR (0.65) | EGFRFLT1PIK3CAPIK3CGKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0837063-A1 | 4-Aminoquinazoline derivatives | PFIZER INC. (US) | 1998-04-22 | — | — | EP | claimed |
| US-6225318-B1 | 4-aminoquinazolone derivatives | PFIZER INC | 2001-05-01 | — | — | US | disclosed |
| EP-0837063-A1 | 4-Aminoquinazoline derivatives | PFIZER INC. (US) | 1998-04-22 | — | — | EP | disclosed |