Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA2 | P42262 | 17/20 | 0.63 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12723923 | 1.00 | GRIA2 (0.63) | GRIA2CA1CA2ACHE | |
| SCHEMBL1591094 | 0.86 | GRIA2 (0.73) | GRIA2 | |
| SCHEMBL1591080 | 0.84 | GRIA2 (0.65) | GRIA2 | |
| SCHEMBL27812897 | 0.81 | GRIA2 (0.65) | GRIA2 | |
| SCHEMBL1591016 | 0.80 | GRIA2 (0.61) | GRIA2 | |
| SCHEMBL1591019 | 0.80 | GRIA2 (0.61) | GRIA2 | |
| SCHEMBL7902024 | 0.78 | CA1 (0.56) | CA1CA2ACHE | |
| SCHEMBL7973199 | 0.78 | CA1 (0.56) | CA1CA2ACHE | |
| SCHEMBL1590736 | 0.78 | GRIA2 (1.00) | GRIA2 | |
| SCHEMBL1590739 | 0.78 | GRIA2 (1.00) | GRIA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2297110-B1 | INDANE DERIVATIVES AS AMPA RECEPTOR MODULATORS | MERCK SHARP & DOHME (NL) | 2015-05-20 | — | — | EP | disclosed |
| US-8536214-B2 | Indane derivatives as AMPA receptor modulators | N.V. ORGANON (NL) | 2013-09-17 | — | — | US | disclosed |
| WO-2009147167-A1 | INDANE DERIVATIVES AS AMPA RECEPTOR MODULATORS | N.V. ORGANON (NL) | 2009-12-10 | — | — | WO | disclosed |