SCHEMBL7967068

SCHEMBL7967068

Bc1ccc2c(c1)C(=O)CC(c1ccc(F)cc1)O2

nearest known ligand 0.66

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
MAOB P27338 17/20 0.66
AR P10275 3/20 0.53
KDM4E B2RXH2 1/20 0.50
ADORA3 P0DMS8 1/20 0.50
CYP19A1 P11511 1/20 0.50
HSD17B10 Q99714 1/20 0.50
ABCB1 P08183 1/20 0.50
ABCG2 Q9UNQ0 1/20 0.50
RAB9A P51151 1/20 0.48
KMT2A Q03164 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7958829 0.87 AR (0.69) MAOBARKDM4EADORA3CYP19A1
SCHEMBL1822266 0.83 MAOB (0.66) MAOBARADORA3CYP19A1RAB9A
SCHEMBL4360454 0.83 AR (0.77) MAOBARADORA3CYP19A1RAB9A
SCHEMBL9825807 0.81 MAOB (0.78) MAOBARKDM4EADORA3CYP19A1
SCHEMBL30777574 0.80 MAOB (0.81) MAOBARKDM4ECYP19A1HSD17B10
SCHEMBL18893710 0.80 MAOB (0.81) MAOBARKDM4ECYP19A1HSD17B10
SCHEMBL2474548 0.80 MAOB (1.00) MAOBARKDM4EADORA3CYP19A1
SCHEMBL2474549 0.80 MAOB (1.00) MAOBARKDM4EADORA3CYP19A1
SCHEMBL7958698 0.78 AR (0.52) MAOBARKDM4EADORA3CYP19A1
SCHEMBL7956418 0.78 KDM4E (0.68) MAOBARKDM4EADORA3CYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010021680-A2 INHIBITORS OF BETA-SECRETASE VITAE PHARMACEUTICALS, INC. (US) 2010-02-25 WO disclosed