Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.49 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.49 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.49 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.49 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.49 |
| ▸ | TNF | P01375 | 3/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.47 |
| ▸ | ABL1 | P00519 | 2/20 | 0.47 |
| ▸ | RAF1 | P04049 | 2/20 | 0.47 |
| ▸ | LYN | P07948 | 2/20 | 0.47 |
| ▸ | SRC | P12931 | 2/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.47 |
| ▸ | HCK | P08631 | 2/20 | 0.47 |
| ▸ | CIT | O14578 | 1/20 | 0.47 |
| ▸ | MUSK | O15146 | 1/20 | 0.47 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.47 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.47 |
| ▸ | STK10 | O94804 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL296936 | 0.90 | MAPK14 (0.57) | MAPK14MAPK12MAPK13MAPK11DDR2 | |
| SCHEMBL6261368 | 0.82 | MAPK14 (0.48) | MAPK14MAPK12MAPK13MAPK11DDR2 | |
| SCHEMBL6719679 | 0.78 | MAPK14 (0.76) | MAPK14MAPK12MAPK13MAPK11DDR2 | |
| SCHEMBL295875 | 0.77 | TNF (0.77) | MAPK14MAPK12MAPK13MAPK11DDR2 | |
| SCHEMBL20876989 | 0.77 | TNF (0.77) | MAPK14MAPK12MAPK13MAPK11DDR2 | |
| SCHEMBL6411778 | 0.76 | MAPK14 (0.41) | MAPK14MAPK12MAPK13MAPK11DDR2 | |
| SCHEMBL294693 | 0.76 | MAPK14 (0.72) | MAPK14MAPK12MAPK13MAPK11DDR2 | |
| SCHEMBL7964926 | 0.75 | MAPK14 (0.78) | MAPK14MAPK12MAPK13MAPK11DDR2 | |
| SCHEMBL6053696 | 0.73 | MAPK14 (0.54) | MAPK14MAPK12MAPK13MAPK11DDR2 | |
| SCHEMBL6719685 | 0.73 | MAPK14 (0.46) | MAPK14MAPK12MAPK13MAPK11DDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6319921-B1 | FOR TREATMENT OF RHEUMATOID ARTHRITIS, MULTIPLE SCLEROSIS, GUILLAIN-BARRE SYNDROME, CROHN'S DISEASE ULCERATIVE COLITIS, PSORIASIS, GRAFT VERSUS HOST DISEASE, SYSTEMIC LUPUS ERYTHEMATOSUS AND DIABETES | BOERHINGER INGELHEIM PHARMACEUTICALS, INC. | 2001-11-20 | — | — | US | claimed |