Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 19/20 | 0.52 |
| ▸ | ESR2 | Q92731 | 11/20 | 0.45 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.42 |
| ▸ | TUBB | P07437 | 1/20 | 0.42 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.42 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.42 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.42 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.42 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.42 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.42 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.42 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.42 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.42 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.42 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.42 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.42 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7618234 | 0.84 | ESR1 (0.49) | ESR1ESR2 | |
| SCHEMBL7624121 | 0.84 | ESR1 (0.47) | ESR1ESR2TUBB4ATUBBTUBA3C | |
| SCHEMBL7967564 | 0.83 | ESR1 (0.47) | ESR1ESR2TUBB4ATUBBTUBA3C | |
| SCHEMBL7627618 | 0.80 | ESR1 (0.66) | ESR1ESR2MEN1ALDH1A1LMNA | |
| SCHEMBL7621346 | 0.80 | ESR1 (0.68) | ESR1ESR2MEN1ALDH1A1LMNA | |
| SCHEMBL7618336 | 0.79 | ESR1 (0.70) | ESR1ESR2MEN1ALDH1A1LMNA | |
| SCHEMBL8901779 | 0.78 | ESR1 (0.47) | ESR1ESR2MEN1ALDH1A1LMNA | |
| SCHEMBL7617253 | 0.77 | ESR1 (0.58) | ESR1ESR2MEN1ALDH1A1LMNA | |
| SCHEMBL7623541 | 0.77 | ESR1 (0.64) | ESR1ESR2MEN1ALDH1A1LMNA | |
| SCHEMBL6976728 | 0.74 | ESR1 (0.81) | ESR1ESR2MEN1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291484-B1 | TREATMENT OF THE VARIOUS MEDICAL CONDITIONS ASSOCIATED WITH POSTMENOPAUSAL SYNDROME | ELI LILLY AND COMPANY | 2001-09-18 | — | — | US | disclosed |
| US-6090843-A | POSTMENOPAUSE DISEASES; ESTROGEN SENSITIVITY; BONE DISORDERS | ELI LILLY AND COMPANY (US) | 2000-07-18 | — | — | US | disclosed |