Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 9/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | CA1 | P00915 | 4/20 | 0.52 |
| ▸ | CA2 | P00918 | 2/20 | 0.52 |
| ▸ | CA7 | P43166 | 2/20 | 0.52 |
| ▸ | CA9 | Q16790 | 2/20 | 0.52 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.51 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | AGXT | P21549 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7965700 | 1.00 | TACR1 (0.59) | TACR1TSHRCA1CA2CA7 | |
| SCHEMBL2781643 | 1.00 | TACR1 (0.59) | TACR1TSHRCA1CA2CA7 | |
| Hydrochloric Acid SCHEMBL8935783 | 0.98 | TACR1 (0.58) | TACR1TSHRCA1CA2CA7 | |
| SCHEMBL18394417 | 0.91 | TACR1 (0.63) | TACR1TSHRCA1CA2CA7 | |
| SCHEMBL3595674 | 0.86 | TACR1 (0.54) | TACR1TSHRCA1CA2CA7 | |
| SCHEMBL18579714 | 0.86 | TACR1 (0.73) | TACR1TSHRCA1CA2CA7 | |
| SCHEMBL903590 | 0.86 | TACR1 (0.73) | TACR1TSHRCA1CA2CA7 | |
| SCHEMBL18579716 | 0.86 | TACR1 (0.73) | TACR1TSHRCA1CA2CA7 | |
| SCHEMBL335619 | 0.84 | TACR1 (0.56) | TACR1TSHRCA1CA2CA7 | |
| Hydrochloric Acid SCHEMBL6735402 | 0.84 | TACR1 (0.71) | TACR1TSHRCA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6274715-B1 | SEMISYNTHETIC MACROLIDES, USEFUL IN BACTERIAL INFECTIONS TREATMENT AND PREVENTION, HAS LESS POTENTIAL FOR DEVELOPING RESISTANCE, IMPROVED OR MODIFIED PROFILES OF DESIRED GRAM-NEGATIVE ACTIVITY | ABBOTT LABORATORIES | 2001-08-14 | — | — | US | disclosed |
| EP-0961776-A1 | TRICYCLIC ERYTHROMYCIN DERIVATIVES | Abbott Laboratories (US) | 1999-12-08 | — | — | EP | disclosed |
| WO-1998030574-A1 | TRICYCLIC ERYTHROMYCIN DERIVATIVES | ABBOTT LABORATORIES (US) | 1998-07-16 | — | — | WO | disclosed |