Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 4/20 | 0.38 |
| ▸ | AVPR1A | P37288 | 4/20 | 0.38 |
| ▸ | AVPR1B | P47901 | 4/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.37 |
| ▸ | MAP3K7 | O43318 | 4/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7966173 | 0.99 | AVPR2 (0.38) | AVPR2AVPR1AAVPR1BHRH4MAP3K7 | |
| SCHEMBL7964371 | 0.94 | AVPR2 (0.40) | AVPR2AVPR1AAVPR1BHRH4MAP3K7 | |
| SCHEMBL7962320 | 0.94 | AVPR2 (0.39) | AVPR2AVPR1AAVPR1BHRH4MAP3K7 | |
| Hydrochloric Acid SCHEMBL7962159 | 0.94 | AVPR2 (0.38) | AVPR2AVPR1AAVPR1BHRH4MAP3K7 | |
| SCHEMBL7966373 | 0.94 | AVPR2 (0.38) | AVPR2AVPR1AAVPR1BHRH4MAP3K7 | |
| Hydrochloric Acid SCHEMBL7968775 | 0.93 | AVPR2 (0.38) | AVPR2AVPR1AAVPR1BHRH4MAP3K7 | |
| SCHEMBL7568896 | 0.93 | AVPR2 (0.39) | AVPR2AVPR1AAVPR1BHRH4MAP3K7 | |
| SCHEMBL7570557 | 0.93 | AVPR2 (0.38) | AVPR2AVPR1AAVPR1BHRH4MAP3K7 | |
| Hydrochloric Acid SCHEMBL7966156 | 0.93 | AVPR2 (0.39) | AVPR2AVPR1AAVPR1BHRH4MAP3K7 | |
| Hydrochloric Acid SCHEMBL7965642 | 0.92 | AVPR2 (0.37) | AVPR2AVPR1AAVPR1BHRH4MAP3K7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316482-B1 | FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |
| US-6207693-B1 | Benzamide derivatives having a vasopressin antagonistic activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |