Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | PTGES | O14684 | 2/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CCND3 | P30281 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7746666 | 0.83 | KDM4E (0.41) | POLBKDRNPC1KDM4EALDH1A1 | |
| SCHEMBL7744215 | 0.71 | KDM4E (0.39) | FGFR1KDRNPC1KDM4EHPGD | |
| SCHEMBL7982491 | 0.70 | KDM4E (0.38) | POLBKDRNPC1KDM4EHPGD | |
| SCHEMBL7744109 | 0.70 | KDR (0.54) | KDRCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL11117825 | 0.70 | NPC1 (0.59) | POLBCHEK1FGFR1CYP1A2NPC1 | |
| SCHEMBL15620225 | 0.68 | MAPT (0.47) | POLBCDK2KDM4EHPGDALDH1A1 | |
| SCHEMBL15620466 | 0.66 | KDM4E (0.47) | POLBCDK2NPC1KDM4EHPGD | |
| SCHEMBL15621527 | 0.65 | MAPT (0.46) | POLBCDK2KDM4EHPGDALDH1A1 | |
| SCHEMBL1347677 | 0.65 | NPC1 (0.77) | POLBALOX5NPC1KDM4EHPGD | |
| SCHEMBL2524920 | 0.64 | POLB (0.62) | NOX1POLBIDO1ALOX5CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6228871-B1 | THIAZOLE OR OXAZOLE DERIVATIVE TYROSINE KINASE INHIBITORS; ANTICARCINOGENIC AGENTS; AUTOIMMUNE DISEASES; DIABETIC RETINOPATHY | MERCK & CO., INC. | 2001-05-08 | — | — | US | disclosed |