Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.62 |
| ▸ | RAB9A | P51151 | 8/20 | 0.62 |
| ▸ | MEN1 | O00255 | 5/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | CASP3 | P42574 | 2/20 | 0.54 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.54 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.54 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3644692 | 0.80 | KCNK3 (0.71) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL4254257 | 0.78 | NPC1 (1.00) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL30369807 | 0.78 | NPC1 (1.00) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL12218560 | 0.77 | NPC1 (0.69) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL4250694 | 0.77 | NPC1 (0.71) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL23844170 | 0.77 | NPC1 (0.76) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL8250624 | 0.76 | HDAC8 (0.56) | MEN1KMT2AMAPTKDM4ELMNA | |
| SCHEMBL8251251 | 0.76 | HDAC8 (0.56) | MEN1KMT2AMAPTKDM4ELMNA | |
| SCHEMBL12052142 | 0.76 | HDAC8 (0.56) | MEN1KMT2AMAPTKDM4ELMNA | |
| SCHEMBL30277604 | 0.76 | SMN1; SMN2 (0.66) | NPC1RAB9AMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6268387-B1 | INHIBITORS OF THE ENZYME 15-LIPOXYGENASE AND ARE INHIBITORS OF MONOCYTE CHEMOTAXIS. | WARNER-LAMBERT COMPANY | 2001-07-31 | — | — | US | disclosed |