Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 10/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | MLYCD | O95822 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9196040 | 1.00 | TRPV1 (0.47) | TRPV1HTR2AHTR2CHTR2BMLYCD | |
| SCHEMBL7969391 | 1.00 | TRPV1 (0.47) | TRPV1HTR2AHTR2CHTR2BMLYCD | |
| SCHEMBL9196045 | 1.00 | TRPV1 (0.47) | TRPV1HTR2AHTR2CHTR2BMLYCD | |
| SCHEMBL7969397 | 1.00 | TRPV1 (0.47) | TRPV1HTR2AHTR2CHTR2BMLYCD | |
| SCHEMBL21731473 | 0.90 | CNR2 (0.43) | TRPV1HTR2AHTR2CHTR2BHDAC4 | |
| SCHEMBL22321372 | 0.89 | ESR2 (0.47) | TRPV1HTR2AHTR2CHTR2BMLYCD | |
| SCHEMBL731258 | 0.89 | ESR2 (0.47) | TRPV1HTR2AHTR2CHTR2BMLYCD | |
| SCHEMBL1515236 | 0.82 | HTR2C (0.47) | HTR2AHTR2CHTR2BMLYCDPARP10 | |
| SCHEMBL29878889 | 0.82 | HTR2C (0.47) | HTR2AHTR2CHTR2BMLYCDPARP10 | |
| SCHEMBL23363446 | 0.79 | KDM1A (0.49) | HTR2AHTR2CHTR2BHDAC4DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291520-B1 | INHIBIT THE ENZYME LIPOXYGENASE; TREATMENT OR ALLEVIATION OF INFLAMMATORY DISEASES, ALLERGIC CONDITIONS AND CARDIOVASCULAR DISEASES | PFIZER | 2001-09-18 | — | — | US | disclosed |
| EP-0559743-B1 | NOVEL HYDROXAMIC ACID AND N-HYDROXYUREA DERIVATIVES AND THEIR USE | PFIZER (US) | 1995-03-08 | — | — | EP | disclosed |
| EP-0559743-A1 | NOVEL HYDROXAMIC ACID AND N-HYDROXYUREA DERIVATIVES AND THEIR USE. | PFIZER HOSPITAL PROD (US) | 1993-09-15 | — | — | EP | disclosed |
| WO-1992009566-A1 | NOVEL HYDROXAMIC ACID AND N-HYDROXYUREA DERIVATIVES AND THEIR USE | PFIZER INC. (US) | 1992-06-11 | — | — | WO | disclosed |