Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 17/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7980203 | 0.91 | LCK (0.83) | LCKKDM4E | |
| SCHEMBL7970006 | 0.88 | LCK (0.78) | LCK | |
| SCHEMBL7970028 | 0.87 | LCK (0.77) | LCKKDM4EMAPT | |
| SCHEMBL7983440 | 0.85 | LCK (0.74) | LCKKDM4E | |
| SCHEMBL7987162 | 0.84 | LCK (0.73) | LCKKDM4E | |
| SCHEMBL7983808 | 0.83 | LCK (0.80) | LCK | |
| SCHEMBL7969867 | 0.82 | LCK (0.69) | LCKMAPT | |
| SCHEMBL7984726 | 0.81 | LCK (0.72) | LCK | |
| SCHEMBL7979866 | 0.81 | LCK (1.00) | LCK | |
| SCHEMBL7981902 | 0.81 | LCK (1.00) | LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | claimed |
| WO-1999009845-A1 | IMIDAZOQUINOXALINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-03-04 | — | — | WO | claimed |
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | disclosed |