Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.53 |
| ▸ | ATM | Q13315 | 4/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 7/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 7/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 7/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 7/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7959041 | 0.82 | KDM4E (0.52) | KDM4EATMHTTL3MBTL1ALDH1A1 | |
| SCHEMBL1822531 | 0.82 | KDM4E (0.52) | KDM4EATMHTTL3MBTL1ALDH1A1 | |
| SCHEMBL7972456 | 0.79 | KDM4E (0.49) | KDM4EATMHTTL3MBTL1ALDH1A1 | |
| SCHEMBL12299672 | 0.79 | KDM4E (0.49) | KDM4EATMHTTL3MBTL1ALDH1A1 | |
| SCHEMBL7959376 | 0.79 | KDM4E (0.54) | KDM4EATMHTTL3MBTL1ALDH1A1 | |
| SCHEMBL1820935 | 0.77 | KDM4E (0.49) | KDM4EATMHTTL3MBTL1ALDH1A1 | |
| SCHEMBL1821384 | 0.76 | KDM4E (0.46) | KDM4EATMHTTL3MBTL1ALDH1A1 | |
| SCHEMBL1822926 | 0.76 | KDM4E (0.48) | KDM4EATMHTTL3MBTL1ALDH1A1 | |
| SCHEMBL1822792 | 0.75 | KDM4E (0.47) | KDM4EATMHTTL3MBTL1ALDH1A1 | |
| SCHEMBL1822402 | 0.75 | KDM4E (0.44) | KDM4EATMHTTL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010021680-A2 | INHIBITORS OF BETA-SECRETASE | VITAE PHARMACEUTICALS, INC. (US) | 2010-02-25 | — | — | WO | disclosed |