Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 4/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | AVPR2 | P30518 | 2/20 | 0.34 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.34 |
| ▸ | AVPR1B | P47901 | 2/20 | 0.34 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.33 |
| ▸ | TUBB | P07437 | 1/20 | 0.33 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.33 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.33 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.33 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.33 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.33 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.33 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.33 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.33 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.33 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7954164 | 0.92 | AVPR2 (0.39) | MAP3K7PTK2LRRK2KMT2AATM | |
| Hydrochloric Acid SCHEMBL7968028 | 0.91 | AVPR2 (0.39) | MAP3K7PTK2LRRK2KMT2AATM | |
| SCHEMBL7975517 | 0.90 | MAP3K7 (0.36) | MAP3K7LRRK2AVPR2AVPR1AAVPR1B | |
| SCHEMBL7975530 | 0.90 | HRH4 (0.36) | MAP3K7AVPR2AVPR1AAVPR1B | |
| SCHEMBL7978093 | 0.89 | MAP3K7 (0.35) | MAP3K7AVPR2AVPR1AAVPR1BIRAK4 | |
| Hydrochloric Acid SCHEMBL7962164 | 0.89 | HRH4 (0.35) | MAP3K7PTK2AVPR2AVPR1AAVPR1B | |
| SCHEMBL7975515 | 0.89 | HRH4 (0.35) | MAP3K7AVPR2AVPR1AAVPR1B | |
| Hydrochloric Acid SCHEMBL7480957 | 0.89 | MAP3K7 (0.43) | MAP3K7PTK2IRAK4HDAC3HDAC4 | |
| Hydrochloric Acid SCHEMBL7968777 | 0.89 | HRH4 (0.35) | MAP3K7AVPR2AVPR1AAVPR1B | |
| Hydrochloric Acid SCHEMBL7476852 | 0.89 | MAPK11 (0.36) | MAP3K7LRRK2HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316482-B1 | FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |
| US-6207693-B1 | Benzamide derivatives having a vasopressin antagonistic activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |