Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 9/20 | 0.59 |
| ▸ | IP6K1 | Q92551 | 5/20 | 0.54 |
| ▸ | KDM4A | O75164 | 1/20 | 0.51 |
| ▸ | KDM4B | O94953 | 1/20 | 0.51 |
| ▸ | KDM5C | P41229 | 1/20 | 0.51 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.51 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.51 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.50 |
| ▸ | PIM1 | P11309 | 2/20 | 0.50 |
| ▸ | AKT1 | P31749 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 1/20 | 0.50 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.50 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6837616 | 0.85 | PARP1 (0.54) | PARP1IP6K1KDM4AKDM4BKDM5C | |
| SCHEMBL869256 | 0.78 | PARP1 (0.59) | PARP1IP6K1KDM4AKDM4BKDM5C | |
| SCHEMBL7657502 | 0.78 | PARP1 (0.59) | PARP1IP6K1KDM4AKDM4BKDM5C | |
| SCHEMBL669366 | 0.78 | PARP1 (0.59) | PARP1IP6K1KDM4AKDM4BKDM5C | |
| SCHEMBL7221768 | 0.77 | PARP1 (0.62) | PARP1IP6K1CHEK1PIM1AKT1 | |
| SCHEMBL6360085 | 0.76 | IP6K1 (0.52) | PARP1IP6K1KDM4AKDM4BKDM5C | |
| SCHEMBL2081677 | 0.74 | PARP1 (1.00) | PARP1IP6K1CHEK1PIM1AKT1 | |
| SCHEMBL6769666 | 0.74 | IP6K1 (0.50) | PARP1IP6K1KDM4AKDM4BKDM5C | |
| SCHEMBL21331974 | 0.74 | PARP1 (0.54) | PARP1IP6K1KDM4AKDM4BKDM5C | |
| SCHEMBL6364139 | 0.74 | PARP1 (0.50) | PARP1IP6K1KDM4AKDM4BKDM5C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6174889-B1 | PROTEIN TYROSINE KINASE INHIBITORS RELATED TO BIOISOSTERES OF QUINOLINE AND QUINAZOLINE DERIVATIVES; ANTICARCINOGENIC AND -TUMOR AGENTS; PSORIASIS; RESTENOSIS; RHEUMATOID ARTHRITIS, AUTOIMMUNE DISEASE, ALLERGY, ASTHMA AND GRAFT REJECTION | GLAXO WELLCOME INC. | 2001-01-16 | — | — | US | claimed |