Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 19/20 | 0.68 |
| ▸ | ESR2 | Q92731 | 11/20 | 0.68 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | PLD2 | O14939 | 1/20 | 0.57 |
| ▸ | KDM1A | O60341 | 1/20 | 0.57 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | C5 | P01031 | 1/20 | 0.57 |
| ▸ | FYN | P06241 | 1/20 | 0.57 |
| ▸ | PGR | P06401 | 1/20 | 0.57 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7971665 | 0.98 | ESR1 (0.66) | ESR1ESR2MEN1ALDH1A1LMNA | |
| SCHEMBL8082359 | 0.96 | ESR1 (0.68) | ESR1ESR2CNR1TUBB4ATUBB | |
| SCHEMBL8082459 | 0.92 | ESR1 (0.68) | ESR1ESR2MEN1ALDH1A1LMNA | |
| SCHEMBL11549428 | 0.90 | ESR1 (0.73) | ESR1ESR2MEN1ALDH1A1LMNA | |
| SCHEMBL11546753 | 0.90 | ESR1 (0.69) | ESR1ESR2MEN1ALDH1A1LMNA | |
| SCHEMBL16380497 | 0.89 | ESR1 (0.67) | ESR1ESR2CNR1TUBB4ATUBB | |
| SCHEMBL16347638 | 0.89 | ESR1 (0.66) | ESR1ESR2MEN1ALDH1A1LMNA | |
| SCHEMBL16345819 | 0.89 | ESR1 (0.66) | ESR1ESR2MEN1ALDH1A1LMNA | |
| SCHEMBL11552962 | 0.88 | ESR1 (0.72) | ESR1ESR2MEN1ALDH1A1LMNA | |
| SCHEMBL1665792 | 0.87 | CNR1 (0.70) | ESR1ESR2MEN1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291484-B1 | TREATMENT OF THE VARIOUS MEDICAL CONDITIONS ASSOCIATED WITH POSTMENOPAUSAL SYNDROME | ELI LILLY AND COMPANY | 2001-09-18 | — | — | US | disclosed |
| EP-0902025-A2 | Benzothiophenes for treatment of estrogen related conditions | ELI LILLY AND COMPANY (US) | 1999-03-17 | — | — | EP | disclosed |