Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 11/20 | 0.43 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29882957 | 0.79 | PI4KA (0.50) | GRM1EGFRMAP4K4 | |
| SCHEMBL6419640 | 0.79 | PI4KA (0.50) | GRM1EGFRMAP4K4 | |
| SCHEMBL3320194 | 0.79 | PDE4A (0.47) | GRM1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL17804471 | 0.76 | EGFR (0.50) | GRM1EGFRERBB2NOS3NOS1 | |
| SCHEMBL7654880 | 0.76 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DEGFR | |
| SCHEMBL867350 | 0.76 | PDE4A (0.44) | GRM1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL27392368 | 0.76 | PDE4A (0.44) | GRM1PDE4APDE4BPDE4CPDE4D | |
| Hydrochloric Acid SCHEMBL28505948 | 0.74 | PDE4A (0.42) | GRM1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6590076 | 0.72 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DEGFR | |
| SCHEMBL21219880 | 0.72 | ENPP1 (0.50) | PDE4APDE4BPDE4CPDE4DEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6174889-B1 | PROTEIN TYROSINE KINASE INHIBITORS RELATED TO BIOISOSTERES OF QUINOLINE AND QUINAZOLINE DERIVATIVES; ANTICARCINOGENIC AND -TUMOR AGENTS; PSORIASIS; RESTENOSIS; RHEUMATOID ARTHRITIS, AUTOIMMUNE DISEASE, ALLERGY, ASTHMA AND GRAFT REJECTION | GLAXO WELLCOME INC. | 2001-01-16 | — | — | US | claimed |