Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 15/20 | 0.69 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2919286 | 0.86 | PDGFRB (0.62) | PDGFRBACHEBACE1ENPP1MTNR1B | |
| SCHEMBL8675057 | 0.85 | PDGFRB (0.83) | PDGFRBPDGFRA | |
| SCHEMBL2913895 | 0.82 | PDGFRB (1.00) | PDGFRBPDGFRA | |
| SCHEMBL2923033 | 0.82 | PDGFRB (1.00) | PDGFRBPDGFRA | |
| SCHEMBL2914939 | 0.79 | PDGFRB (0.54) | PDGFRBENPP1HTT | |
| SCHEMBL2942129 | 0.75 | PDGFRB (1.00) | PDGFRBPDGFRA | |
| SCHEMBL2918133 | 0.74 | HTT (0.54) | PDGFRBACHEBACE1ENPP1HTT | |
| SCHEMBL2913022 | 0.73 | PDGFRB (0.55) | PDGFRBENPP1HTT | |
| SCHEMBL2924356 | 0.71 | PDGFRB (1.00) | PDGFRBPDGFRA | |
| SCHEMBL2914263 | 0.71 | PDGFRB (0.49) | PDGFRBENPP1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207667-B1 | USEFUL FOR THE TREATMENT OF CELL-PROLIFERATIVE DISEASES SUCH AS ARTERIOSCLEROSIS, VASCULAR REOBSTRUCTION, CANCER AND GLOMERULOSCLEROSIS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |