Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 5/20 | 0.52 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.52 |
| ▸ | FNTA | P49354 | 13/20 | 0.49 |
| ▸ | FNTB | P49356 | 13/20 | 0.49 |
| ▸ | PGGT1B | P53609 | 11/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7849345 | 0.91 | CYP11B1 (0.47) | CYP11B1CYP11B2FNTAFNTBPGGT1B | |
| SCHEMBL7831475 | 0.90 | FNTA (0.51) | CYP11B1CYP11B2FNTAFNTBPGGT1B | |
| SCHEMBL7848326 | 0.87 | FNTA (0.50) | CYP11B1CYP11B2FNTAFNTBPGGT1B | |
| SCHEMBL7960820 | 0.87 | FNTA (0.49) | CYP11B1CYP11B2FNTAFNTBPGGT1B | |
| SCHEMBL7973044 | 0.87 | FNTA (0.56) | CYP11B1CYP11B2FNTAFNTBPGGT1B | |
| SCHEMBL7970850 | 0.85 | FNTA (0.57) | CYP11B1CYP11B2FNTAFNTBPGGT1B | |
| SCHEMBL7839747 | 0.84 | FNTA (0.59) | CYP11B1CYP11B2FNTAFNTBPGGT1B | |
| SCHEMBL7832250 | 0.83 | FNTA (0.58) | CYP11B1CYP11B2FNTAFNTBPGGT1B | |
| SCHEMBL7829982 | 0.79 | FNTA (0.57) | CYP11B1CYP11B2FNTAFNTBPGGT1B | |
| SCHEMBL7840500 | 0.79 | FNTA (0.57) | CYP11B1CYP11B2FNTAFNTBPGGT1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248756-B1 | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. | 2001-06-19 | — | — | US | disclosed |
| US-5891889-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-04-06 | — | — | US | disclosed |