Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7002664 | 0.91 | HRH1 (0.40) | HRH1TP53MAPK1KDM4EALDH1A1 | |
| SCHEMBL6997660 | 0.91 | MAPK1 (0.39) | HRH1GAAKMT2AACHEMAPK1 | |
| SCHEMBL7961305 | 0.89 | KDM4E (0.39) | HRH1KMT2AMAPK1KDM4EHTT | |
| SCHEMBL7961447 | 0.88 | HRH1 (0.38) | HRH1KMT2AACHEMAPK1KDM4E | |
| SCHEMBL7000714 | 0.86 | SMN1; SMN2 (0.41) | HRH1GAAKMT2AMAPK1ALDH1A1 | |
| SCHEMBL7955948 | 0.86 | MEN1 (0.36) | HRH1GAAKMT2AMAPK1HTT | |
| SCHEMBL6993974 | 0.86 | HRH1 (0.40) | HRH1TP53MAPK1KDM4EALDH1A1 | |
| SCHEMBL6992818 | 0.86 | ABCB1 (0.36) | HRH1KMT2AMAPK1HTTLMNA | |
| SCHEMBL7985088 | 0.86 | MAPK1 (0.38) | HRH1GAAKMT2AACHEMAPK1 | |
| SCHEMBL7003238 | 0.85 | TSHR (0.33) | HRH1KMT2AKDM4EALDH1A1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211199-B1 | HISTAMINE AND TACHYKININ RECEPTOR ANTAGONISTS; ANTIASTHMATICS, ANTIEMETICS; RESPIRATORY SYSTEM DISORDERS, INFLAMMATORY BOWEL DISEASE, CONJUNCTIVITIS | AVENTIS PHARMACEUTICALS INC. | 2001-04-03 | — | — | US | disclosed |