Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 16/20 | 0.56 |
| ▸ | FNTB | P49356 | 16/20 | 0.56 |
| ▸ | PGGT1B | P53609 | 13/20 | 0.56 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.53 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7853068 | 0.93 | FNTA (0.65) | FNTAFNTBPGGT1BCYP11B1CYP11B2 | |
| SCHEMBL7973044 | 0.88 | FNTA (0.56) | FNTAFNTBPGGT1BCYP11B1CYP11B2 | |
| SCHEMBL7839062 | 0.87 | FNTA (0.57) | FNTAFNTBPGGT1BCYP11B1CYP11B2 | |
| SCHEMBL7832499 | 0.84 | FNTA (0.53) | FNTAFNTBPGGT1BCYP11B1CYP11B2 | |
| SCHEMBL7848289 | 0.84 | FNTA (0.51) | FNTAFNTBPGGT1BCYP11B1CYP11B2 | |
| SCHEMBL7842379 | 0.84 | CYP11B1 (0.53) | FNTAFNTBPGGT1BCYP11B1CYP11B2 | |
| SCHEMBL7839757 | 0.83 | FNTA (0.65) | FNTAFNTBPGGT1B | |
| SCHEMBL7972330 | 0.83 | FNTA (0.49) | FNTAFNTBPGGT1BCYP11B1CYP11B2 | |
| Trifluoroacetic Acid SCHEMBL7842732 | 0.82 | FNTA (0.52) | FNTAFNTBPGGT1BCYP11B1CYP11B2 | |
| SCHEMBL7840204 | 0.81 | FNTA (0.67) | FNTAFNTBPGGT1BCYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248756-B1 | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. | 2001-06-19 | — | — | US | disclosed |
| US-5891889-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-04-06 | — | — | US | disclosed |