Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 16/20 | 0.78 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.54 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7972985 | 0.89 | LCK (0.75) | LCKMKNK1MKNK2 | |
| SCHEMBL7019359 | 0.88 | LCK (1.00) | LCKMKNK1MKNK2 | |
| SCHEMBL7019366 | 0.88 | LCK (1.00) | LCKMKNK1MKNK2 | |
| SCHEMBL7986654 | 0.86 | LCK (0.74) | LCKMKNK1MKNK2 | |
| SCHEMBL7990610 | 0.85 | LCK (0.74) | LCKMKNK1MKNK2 | |
| SCHEMBL7594757 | 0.85 | LCK (1.00) | LCK | |
| Dimethylamine SCHEMBL7991420 | 0.85 | LCK (0.84) | LCK | |
| SCHEMBL7591154 | 0.84 | LCK (0.68) | LCKMKNK1MKNK2 | |
| SCHEMBL7986922 | 0.84 | LCK (0.83) | LCK | |
| SCHEMBL7103389 | 0.83 | LCK (0.79) | LCKMKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329380-B1 | PYRIMIDINE BENZIMIDIZAZOLE, PYRIMIDINEIMIDAZOLE OR PYRIDINE IMIDAZOLE COMPOUNDS FOR ANTICANCER AGENTS OR ATHEROSCLEROSIS | MERCK & CO., INC. | 2001-12-11 | — | — | US | claimed |
| US-6329380-B1 | PYRIMIDINE BENZIMIDIZAZOLE, PYRIMIDINEIMIDAZOLE OR PYRIDINE IMIDAZOLE COMPOUNDS FOR ANTICANCER AGENTS OR ATHEROSCLEROSIS | MERCK & CO., INC. | 2001-12-11 | — | — | US | disclosed |