Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.40 |
| ▸ | KCNA3 | P22001 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13226486 | 0.74 | AKR1C1 (0.60) | MEN1KMT2ACYP2C9ALDH1A1AKR1C1 | |
| SCHEMBL12540448 | 0.72 | MEN1 (0.53) | MEN1KMT2ACYP2C9ALDH1A1AKR1C1 | |
| SCHEMBL12540446 | 0.72 | MEN1 (0.53) | MEN1KMT2ACYP2C9ALDH1A1AKR1C1 | |
| SCHEMBL31611378 | 0.71 | — | — | |
| Acetic Acid SCHEMBL27502922 | 0.69 | MEN1 (0.55) | MEN1KMT2ACYP2C9ALDH1A1AKR1C1 | |
| SCHEMBL631791 | 0.68 | AKR1C1 (0.68) | MEN1KMT2ACYP2C9AKR1C1HDAC4 | |
| SCHEMBL13226485 | 0.68 | MEN1 (0.47) | MEN1KMT2ACYP2C9AKR1C1KCNA3 | |
| SCHEMBL16137494 | 0.68 | MEN1 (0.47) | MEN1KMT2ACYP2C9AKR1C1KCNA3 | |
| SCHEMBL7810392 | 0.67 | MEN1 (0.63) | MEN1KMT2ACYP2C9ALDH1A1AKR1C1 | |
| SCHEMBL11569214 | 0.67 | MEN1 (0.76) | MEN1KMT2ACYP2C9ALDH1A1AKR1C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218406-B1 | AS ANTITUMOR AND ANTILEUKEMIC AGENTS | AVENTIS PHARMA S.A. (FR) | 2001-04-17 | — | — | US | disclosed |
| US-6124465-A | Farnesyl transferase inhibitors, their preparation, the pharmaceutical compositions which contain them and their use in the preparation of medicaments | RHONE-POULENC S.A. (FR) | 2000-09-26 | — | — | US | disclosed |
| US-6013662-A | ANTITUMOR, ANTICARCINOGENIC AGENTS | RHONE-POULENC RORER S.A. (FR) | 2000-01-11 | — | — | US | disclosed |