Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 8/20 | 0.38 |
| ▸ | PTGER3 | P43115 | 8/20 | 0.38 |
| ▸ | PTGER2 | P43116 | 8/20 | 0.38 |
| ▸ | PTGER1 | P34995 | 6/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.31 |
| ▸ | CDC25A | P30304 | 1/20 | 0.31 |
| ▸ | CDC25B | P30305 | 1/20 | 0.31 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7972867 | 0.80 | KDM4E (0.35) | PTGER4PTGER3PTGER2PTGER1KDM4E | |
| SCHEMBL8179854 | 0.80 | KDM4E (0.35) | PTGER4PTGER3PTGER2PTGER1KDM4E | |
| SCHEMBL7973126 | 0.74 | KDM4E (0.40) | KDM4EMAOB | |
| SCHEMBL7973239 | 0.72 | TOP1 (0.32) | CES2CDC25ACDC25BDUSP3 | |
| SCHEMBL8775359 | 0.72 | TRPV1 (0.45) | DUSP3KDM4E | |
| SCHEMBL8775295 | 0.72 | TRPV1 (0.45) | DUSP3KDM4E | |
| SCHEMBL6933381 | 0.72 | TRPV1 (0.45) | DUSP3KDM4E | |
| SCHEMBL6933386 | 0.72 | TRPV1 (0.45) | DUSP3KDM4E | |
| SCHEMBL8775261 | 0.72 | ABHD16A (0.45) | CES2CDC25ACDC25BDUSP3 | |
| SCHEMBL8775675 | 0.72 | ABHD16A (0.45) | CES2CDC25ACDC25BDUSP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6262073-B1 | INHIBITING THE ACTION OF A PRO-INFLAMMATORY CYTOKINE | OXIS INTERNATIONAL INC. | 2001-07-17 | — | — | US | disclosed |
| US-6136832-A | RACEMIC MIXTURES AND ENANTIOMORPHS | OXIS INTERNATIONAL INC. (US) | 2000-10-24 | — | — | US | disclosed |
| US-6005000-A | 5,5-Disubstituted-3, 4-dihydroxy-2(5H)-furanones and methods of use therefor | OXIS INTERNATIONAL, INC. (US) | 1999-12-21 | — | — | US | disclosed |
| EP-0938482-A1 | 5-SUBSTITUTED AND 5,5-DISUBSTITUTED-3,4-DIHYDROXY-2(5H)-FURANONES AND METHODS OF USE THEREFOR | Oxis International, Inc. (US) | 1999-09-01 | — | — | EP | disclosed |
| WO-1998007714-A1 | 5-SUBSTITUTED AND 5,5-DISUBSTITUTED-3,4-DIHYDROXY-2(5H)-FURANONES AND METHODS OF USE THEREFOR | OXIS INTERNATIONAL, INC. (US) | 1998-02-26 | — | — | WO | disclosed |