Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7960335 | 0.94 | CSF1R (0.47) | CSF1RKMT2ASMN1; SMN2LMNAKDM4E | |
| SCHEMBL28734211 | 0.66 | POLB (0.55) | KDM4EPOLBTUBB1TMEM97SIGMAR1 | |
| SCHEMBL13849660 | 0.65 | KDM4E (0.53) | SMN1; SMN2KDM4EPOLBTUBB1TMEM97 | |
| SCHEMBL30335458 | 0.65 | TNKS2 (0.54) | KDM4EPOLBTUBB1TMEM97SIGMAR1 | |
| SCHEMBL22609987 | 0.65 | TNKS2 (0.54) | KDM4EPOLBTUBB1TMEM97SIGMAR1 | |
| SCHEMBL7973381 | 0.64 | TLR7 (0.46) | CSF1RSMN1; SMN2LMNAPOLBALDH1A1 | |
| SCHEMBL2321003 | 0.63 | CSF1R (0.49) | CSF1RSMN1; SMN2KDM4EPOLBALDH1A1 | |
| SCHEMBL28734166 | 0.63 | POLB (0.54) | KMT2AKDM4EPOLBTUBB1MAPT | |
| SCHEMBL81112 | 0.62 | KDM4E (0.63) | KMT2AKDM4EPOLBTUBB1MAPT | |
| SCHEMBL22609995 | 0.62 | KCNH2 (0.57) | KDM4EPOLBTMEM97SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6297250-B1 | USEFUL FOR INHIBITING TRANSPORT OF NUCLEOSIDES OR PURINES ACROSS CELL MEMBRANES, THEREBY TO POTENTIATE THE ACTIVITY OF VARIOUS CYTOTOXIC ANTITUMOR DRUGS | NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) | 2001-10-02 | — | — | US | claimed |