Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.45 |
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.43 |
| ▸ | ESRRA | P11474 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | C5 | P01031 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7570783 | 0.85 | KMT2A (0.58) | KMT2AMEN1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL7564313 | 0.82 | KMT2A (0.46) | KMT2AMEN1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL7563947 | 0.82 | KMT2A (0.47) | KMT2AMEN1SMN1; SMN2MAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL7563379 | 0.82 | KMT2A (0.47) | KMT2AMEN1ADRB2SMN1; SMN2MAPT | |
| SCHEMBL7562882 | 0.81 | KMT2A (0.51) | KMT2AMEN1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL7564327 | 0.78 | QRFPR (0.46) | KMT2AMEN1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL7564256 | 0.76 | KMT2A (0.62) | KMT2AMEN1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL7598693 | 0.74 | KMT2A (0.47) | KMT2AMEN1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL7564016 | 0.74 | KMT2A (0.43) | KMT2AMEN1ADRB2SMN1; SMN2MAPT | |
| SCHEMBL10789145 | 0.73 | KMT2A (0.56) | KMT2AMEN1SMN1; SMN2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001046171-A1 | AMIDINE DERIVATIVES WHICH ARE INHIBITORS OF NITRIC OXIDE SYNTHASE | ASTRAZENECA AB (SE) | 2001-06-28 | — | — | WO | disclosed |
| WO-2001046170-A1 | AMIDINE DERIVATIVES WHICH ARE INHIBITORS OF NITRIC OXIDE SYNTHASE | ASTRAZENECA AB (SE) | 2001-06-28 | — | — | WO | disclosed |