SCHEMBL7974107

SCHEMBL7974107

O=c1nc(CC2CCCC2)[nH]c2ncn(Cc3ccccc3)c12

nearest known ligand 0.52

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CNOT7 Q9UIV1 4/20 0.49
PARN O95453 1/20 0.49
PNP P00491 2/20 0.41
SMN1; SMN2 Q16637 4/20 0.41
ALDH1A1 P00352 2/20 0.41
KMT2A Q03164 1/20 0.41
PDE9A O76083 2/20 0.39
HPGD P15428 1/20 0.39
ADORA2B P29275 1/20 0.38
RXFP1 Q9HBX9 1/20 0.38
GRIN1 Q05586 1/20 0.38
GRIN2B Q13224 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7974098 0.82 KMT2A (0.55) CNOT7PARNPNPSMN1; SMN2ALDH1A1
SCHEMBL7985306 0.82 CNOT7 (0.51) CNOT7PARNPNPSMN1; SMN2ALDH1A1
SCHEMBL7975254 0.81 CNOT7 (0.55) CNOT7PARNPNPSMN1; SMN2ALDH1A1
SCHEMBL7988101 0.81 CNOT7 (0.55) CNOT7PARNPNPSMN1; SMN2ALDH1A1
SCHEMBL7985358 0.81 CNOT7 (0.50) CNOT7PARNPNPSMN1; SMN2ALDH1A1
Hydrochloric Acid SCHEMBL7987472 0.80 CNOT7 (0.54) CNOT7PARNPNPSMN1; SMN2ALDH1A1
SCHEMBL7985476 0.79 CNOT7 (0.53) CNOT7PARNPNPSMN1; SMN2ALDH1A1
SCHEMBL7985640 0.79 CNOT7 (0.53) CNOT7PARNPNPSMN1; SMN2ALDH1A1
SCHEMBL7989411 0.79 CNOT7 (0.53) CNOT7PARNPNPSMN1; SMN2ALDH1A1
SCHEMBL7984366 0.79 CNOT7 (0.53) CNOT7PARNPNPSMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6310070-B1 FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS JAPAN ENERGY CORPORATION (JP) 2001-10-30 US disclosed
EP-0999211-A1 NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF JAPAN ENERGY CORPORATION (JP) 2000-05-10 EP disclosed