Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 7/20 | 0.65 |
| ▸ | JAK2 | O60674 | 11/20 | 0.62 |
| ▸ | JAK3 | P52333 | 6/20 | 0.56 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.56 |
| ▸ | TYK2 | P29597 | 2/20 | 0.51 |
| ▸ | IKBKB | O14920 | 1/20 | 0.51 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | SYK | P43405 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | BCR | P11274 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13073249 | 0.92 | JAK2 (0.63) | JAK1JAK2JAK3PTK2TYK2 | |
| SCHEMBL13882579 | 0.90 | JAK2 (0.60) | JAK1JAK2JAK3PTK2TYK2 | |
| SCHEMBL13073377 | 0.87 | JAK2 (0.71) | JAK1JAK2JAK3PTK2TYK2 | |
| SCHEMBL7977793 | 0.85 | JAK2 (0.81) | JAK1JAK2JAK3PTK2TYK2 | |
| SCHEMBL3657648 | 0.85 | JAK2 (0.71) | JAK1JAK2JAK3PTK2TYK2 | |
| SCHEMBL7977609 | 0.84 | JAK2 (0.70) | JAK1JAK2JAK3PTK2TYK2 | |
| SCHEMBL7976772 | 0.83 | JAK1 (0.84) | JAK1JAK2JAK3PTK2TYK2 | |
| SCHEMBL7974770 | 0.81 | JAK2 (0.71) | JAK1JAK2JAK3PTK2TYK2 | |
| SCHEMBL7975497 | 0.81 | JAK1 (0.61) | JAK1JAK2JAK3PTK2TYK2 | |
| SCHEMBL7974585 | 0.80 | JAK2 (0.62) | JAK1JAK2JAK3PTK2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010010188-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES. | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |