Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 2/20 | 0.53 |
| ▸ | AHCY | P23526 | 3/20 | 0.50 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.50 |
| ▸ | TRDMT1 | O14717 | 1/20 | 0.50 |
| ▸ | TYMP | P19971 | 1/20 | 0.50 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.46 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.46 |
| ▸ | GNMT | Q14749 | 1/20 | 0.46 |
| ▸ | NNMT | P40261 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1068356 | 0.87 | ADORA1 (0.54) | ADORA1AHCYCARM1TRDMT1TYMP | |
| SCHEMBL2107506 | 0.86 | ADORA1 (0.53) | ADORA1AHCYCARM1TRDMT1TYMP | |
| SCHEMBL1318856 | 0.84 | ADORA1 (0.51) | ADORA1AHCYCARM1TRDMT1TYMP | |
| SCHEMBL1582886 | 0.84 | EHMT1 (0.47) | ADORA1AHCYCARM1TRDMT1TYMP | |
| SCHEMBL5580213 | 0.84 | ADORA1 (0.57) | ADORA1AHCYCARM1TRDMT1TYMP | |
| SCHEMBL15993919 | 0.81 | ADORA1 (0.75) | ADORA1TRDMT1TYMP | |
| SCHEMBL16715145 | 0.81 | ADORA1 (0.75) | ADORA1TRDMT1TYMP | |
| SCHEMBL8359104 | 0.81 | ADORA1 (0.75) | ADORA1TRDMT1TYMP | |
| SCHEMBL1068571 | 0.81 | ADORA1 (0.75) | ADORA1TRDMT1TYMP | |
| SCHEMBL1583007 | 0.80 | EHMT1 (0.43) | ADORA1AHCYCARM1TRDMT1TYMP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6281201-B1 | REPLACEMENT OF THE ADENINE MOIETY IN THE (2'-5')OLIGOADENYLATE TRIMER CORE WITH 1H-1,2,4-TRIAZOLE-3-CARBOXAMIDE OR WITH N6-(BENZYLAMINO)PURINE (ADEBN)-MOIETIES HAS RESULTED IN A NEW GROUP OF INHIBITORS OF HIV-1 REPLICATION. | TEMPLE UNIVERSITY- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2001-08-28 | — | — | US | disclosed |
| WO-1998056385-A1 | BASE-MODIFIED DERIVATIVES OF 2',5'-OLIGOADENYLATE AND ANTIVIRAL USES THEREOF | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 1998-12-17 | — | — | WO | disclosed |