Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 9/20 | 0.50 |
| ▸ | F9 | P00740 | 4/20 | 0.50 |
| ▸ | F11 | P03951 | 3/20 | 0.50 |
| ▸ | F7 | P08709 | 3/20 | 0.50 |
| ▸ | PLAU | P00749 | 6/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 6/20 | 0.48 |
| ▸ | F2 | P00734 | 6/20 | 0.47 |
| ▸ | PLG | P00747 | 5/20 | 0.47 |
| ▸ | PLAT | P00750 | 5/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.43 |
| ▸ | HPN | P05981 | 1/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10139876 | 0.88 | HDAC6 (0.52) | F10F9F11F7PLAU | |
| SCHEMBL7975521 | 0.86 | F10 (0.63) | F10F9F11F7PLAU | |
| SCHEMBL7976986 | 0.85 | CHEK2 (0.53) | F10F9F11F7CHEK2 | |
| SCHEMBL7969435 | 0.83 | CHEK2 (0.65) | F10F9F11F7CHEK2 | |
| SCHEMBL7976170 | 0.82 | ITK (0.48) | F10F9F11F7PDE10A | |
| SCHEMBL10139808 | 0.82 | P2RY6 (0.53) | F10F9F11F7PDE10A | |
| SCHEMBL10140064 | 0.82 | F10 (0.46) | F10F9F11F7PLAU | |
| SCHEMBL7961686 | 0.82 | CHEK2 (0.58) | F10F9F11F7CHEK2 | |
| SCHEMBL10139933 | 0.82 | CHEK2 (0.67) | CHEK2 | |
| SCHEMBL7970842 | 0.81 | NPC1 (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2805939-B1 | Heterocyclic compounds as factor IXA inhibitors. | MERCK SHARP & DOHME (US) | 2018-06-27 | — | — | EP | disclosed |
| EP-2805939-A1 | Heterocyclic compounds as factor IXA inhibitors. | Merck Sharp & Dohme Corp. (US) | 2014-11-26 | — | — | EP | disclosed |
| WO-2009143039-A2 | HETEROCYCLIC COMPOUNDS AS FACTOR IXA INHIBITORS | SCHERING CORPORATION (US) | 2009-11-26 | — | — | WO | disclosed |