Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 6/20 | 0.61 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.61 |
| ▸ | PDE10A | Q9Y233 | 8/20 | 0.61 |
| ▸ | GPBAR1 | Q8TDU6 | 6/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5777664 | 0.85 | CYSLTR1 (0.69) | CYSLTR1CYSLTR2PDE10AGPBAR1 | |
| SCHEMBL1694951 | 0.83 | CYSLTR1 (0.76) | CYSLTR1CYSLTR2PDE10AGPBAR1 | |
| SCHEMBL26632681 | 0.82 | CYSLTR1 (0.75) | CYSLTR1CYSLTR2PDE10AGPBAR1 | |
| SCHEMBL26774780 | 0.82 | CYSLTR1 (0.59) | CYSLTR1CYSLTR2PDE10AGPBAR1 | |
| SCHEMBL26632677 | 0.81 | CYSLTR1 (0.76) | CYSLTR1CYSLTR2PDE10AGPBAR1 | |
| SCHEMBL8179931 | 0.80 | PDE10A (0.64) | CYSLTR1CYSLTR2PDE10AGPBAR1 | |
| SCHEMBL7976637 | 0.80 | CYSLTR1 (0.54) | CYSLTR1CYSLTR2PDE10AGPBAR1 | |
| SCHEMBL26771291 | 0.80 | CYSLTR1 (0.75) | CYSLTR1CYSLTR2PDE10AGPBAR1 | |
| SCHEMBL13772898 | 0.80 | CYSLTR1 (0.69) | CYSLTR1CYSLTR2PDE10AGPBAR1 | |
| SCHEMBL13772899 | 0.80 | PDE10A (0.73) | CYSLTR1CYSLTR2PDE10AGPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6214842-B1 | TREATING METABOLIC DISORDERS RELATED TO INSULIN RESISTANCE OR HYPERGLYCEMIA TYPICALLY ASSOCIATED WITH OBESITY OR GLUCOSE INTOLERANCE; TREATING DIABETES TYPES I AND II | WYETH | 2001-04-10 | — | — | US | disclosed |