SCHEMBL7975490

SCHEMBL7975490

Nc1ccc(C(=O)O)c2c1CCCC2

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.44
ALDH1A1 P00352 6/20 0.44
CDC25B P30305 1/20 0.44
CASP6 P55212 1/20 0.44
RCE1 Q9Y256 1/20 0.44
KDM4E B2RXH2 5/20 0.44
KMT2A Q03164 3/20 0.44
GFER P55789 2/20 0.44
RXFP1 Q9HBX9 1/20 0.44
MAPT P10636 5/20 0.42
TDP1 Q9NUW8 3/20 0.42
MEN1 O00255 2/20 0.42
THRB P10828 2/20 0.42
USP2 O75604 1/20 0.42
POLB P06746 1/20 0.42
PKM P14618 1/20 0.42
APEX1 P27695 1/20 0.42
RECQL P46063 1/20 0.42
BLM P54132 1/20 0.42
MCL1 Q07820 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL87519 0.87 CYP1A2 (0.57) CYP1A2ALDH1A1KDM4EKMT2AGFER
SCHEMBL250454 0.85 CYP1A2 (0.55) CYP1A2ALDH1A1KDM4EKMT2AGFER
SCHEMBL982478 0.85 CYP1A2 (0.55) CYP1A2ALDH1A1KDM4EGFERMAPT
SCHEMBL2034342 0.85 CYP1A2 (0.55) CYP1A2ALDH1A1KDM4EKMT2AGFER
SCHEMBL195800 0.85 CYP1A2 (0.55) CYP1A2ALDH1A1KDM4EKMT2AGFER
SCHEMBL3091854 0.85 CYP1A2 (0.55) CYP1A2ALDH1A1KDM4EKMT2AGFER
Cyclohexane SCHEMBL1538047 0.85 CYP1A2 (0.55) CYP1A2ALDH1A1KDM4EKMT2AGFER
SCHEMBL3107923 0.85 CYP1A2 (0.55) CYP1A2ALDH1A1KDM4EKMT2AGFER
SCHEMBL251512 0.83 CYP1A2 (0.57) CYP1A2ALDH1A1KDM4EGFERMAPT
SCHEMBL973641 0.81 CYP1A2 (0.55) CYP1A2ALDH1A1KDM4EGFERALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6172239-B1 PSYCHOLOGICAL, NERVOUS SYSTEM DISORDERS SANOFI (FR) 2001-01-09 US disclosed
US-5965579-A ANTAGONISTS OF THE NEUROTENSIN RECEPTORS; INCREASING AFFINITY FOR HUMAN NEUROTENSIN RECEPTORS SANOFI (FR) 1999-10-12 US disclosed
US-5939449-A NOVEL COMPOUNDS HAVING HIGH AFFINITY FOR THE NEUROTENSIN RECEPTORS SANOFI (FR) 1999-08-17 US disclosed
US-5936123-A COMPOUNDS SUCH AS 3-ISOPROPYL-4-HYDRAZINOBENZOIC ACID AND ITS SALTS SANOFI (FR) 1999-08-10 US disclosed
US-5925661-A NERVOUS SYSTEM DISORDERS SANOFI (FR) 1999-07-20 US disclosed
US-5723483-A NEUROTENSIN ANTAGONIST, HYPOTENSIVE AGENTS AND FOR NEUROPSYCHIATRIC DISORDERS SANOFI (FR) 1998-03-03 US disclosed