Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 14/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | SRC | P12931 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2642021 | 0.89 | FGFR1 (0.65) | FGFR1ALDH1A1HTT | |
| SCHEMBL17940759 | 0.88 | FGFR1 (0.67) | FGFR1ALDH1A1HTTSRC | |
| SCHEMBL23675204 | 0.85 | FGFR1 (0.65) | FGFR1ALDH1A1 | |
| SCHEMBL30033882 | 0.85 | FGFR1 (0.65) | FGFR1ALDH1A1 | |
| SCHEMBL2649006 | 0.84 | FGFR1 (0.67) | FGFR1ALDH1A1 | |
| SCHEMBL28722636 | 0.84 | FGFR1 (0.63) | FGFR1ALDH1A1 | |
| SCHEMBL2654246 | 0.83 | FGFR1 (0.61) | FGFR1ALDH1A1 | |
| SCHEMBL29512158 | 0.82 | FGFR1 (0.72) | FGFR1ALDH1A1HTT | |
| SCHEMBL2568999 | 0.82 | FGFR1 (0.72) | FGFR1ALDH1A1HTT | |
| SCHEMBL25881861 | 0.81 | FGFR1 (0.52) | FGFR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218388-B1 | THERAPY OF PROTEIN TYROSINE KINASE MEDIATED CANCER, ATHEROSCLEROSIS, RESTENOSIS, AND PSORIASIS BY ADMINISTERING BENZIMIDAZOLE DERIVATIVE | WARNER-LAMBERT COMPANY | 2001-04-17 | — | — | US | disclosed |
| US-5990146-A | TREATING PROTEIN TYROSINE KINASE MEDIATED CANCER; ANTICARCINOGENIC AGENTS; ATHEROSCLEROSIS; RESTENOSIS; PSORIASIS; ANTIPROLIFERATIVE AGENTS | WARNER-LAMBERT COMPANY (US) | 1999-11-23 | — | — | US | disclosed |