Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 5/20 | 0.66 |
| ▸ | FGFR1 | P11362 | 11/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.47 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7975678 | 0.99 | SRC (0.64) | SRCFGFR1ALDH1A1HPGDMAPK1 | |
| SCHEMBL7989444 | 0.84 | SRC (0.72) | SRCFGFR1ALDH1A1HPGDMAPK1 | |
| Hydrochloric Acid SCHEMBL7975827 | 0.82 | SRC (0.70) | SRCFGFR1ALDH1A1HPGDMAPK1 | |
| SCHEMBL7993787 | 0.80 | FGFR1 (1.00) | SRCFGFR1HTT | |
| SCHEMBL7975887 | 0.79 | SRC (1.00) | SRCFGFR1ALDH1A1HPGDMAPK1 | |
| Hydrochloric Acid SCHEMBL7993742 | 0.78 | FGFR1 (0.97) | SRCFGFR1HTT | |
| Hydrochloric Acid SCHEMBL7989583 | 0.78 | SRC (0.97) | SRCFGFR1ALDH1A1HPGDMAPK1 | |
| SCHEMBL7989967 | 0.77 | FGFR1 (0.71) | SRCFGFR1HTT | |
| SCHEMBL7986692 | 0.76 | FGFR1 (0.70) | SRCFGFR1HTT | |
| Hydrochloric Acid SCHEMBL7993360 | 0.76 | FGFR1 (0.69) | SRCFGFR1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218388-B1 | THERAPY OF PROTEIN TYROSINE KINASE MEDIATED CANCER, ATHEROSCLEROSIS, RESTENOSIS, AND PSORIASIS BY ADMINISTERING BENZIMIDAZOLE DERIVATIVE | WARNER-LAMBERT COMPANY | 2001-04-17 | — | — | US | disclosed |
| US-5990146-A | TREATING PROTEIN TYROSINE KINASE MEDIATED CANCER; ANTICARCINOGENIC AGENTS; ATHEROSCLEROSIS; RESTENOSIS; PSORIASIS; ANTIPROLIFERATIVE AGENTS | WARNER-LAMBERT COMPANY (US) | 1999-11-23 | — | — | US | disclosed |