Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 9/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14484081 | 0.84 | EPAS1 (0.53) | EPAS1MAPTKDM4EALDH1A1HSD17B10 | |
| SCHEMBL19736140 | 0.80 | EPAS1 (0.49) | EPAS1MAPTEPHX2GAATP53 | |
| SCHEMBL19728699 | 0.80 | EPAS1 (0.49) | EPAS1MAPTALDH1A1EPHX2TP53 | |
| SCHEMBL29383551 | 0.80 | EPAS1 (0.49) | EPAS1MAPTEPHX2TP53SMN1; SMN2 | |
| SCHEMBL10764963 | 0.80 | EPAS1 (0.49) | EPAS1MAPTKDM4EALDH1A1HSD17B10 | |
| SCHEMBL19667984 | 0.79 | EPAS1 (0.59) | EPAS1MAPTKDM4EALDH1A1HSD17B10 | |
| SCHEMBL7085874 | 0.78 | EPAS1 (0.46) | EPAS1MAPTKDM4EALDH1A1HSD17B10 | |
| SCHEMBL2480253 | 0.78 | EPAS1 (0.50) | EPAS1MAPTKDM4EALDH1A1GAA | |
| SCHEMBL7085876 | 0.78 | EPAS1 (0.46) | EPAS1MAPTKDM4EALDH1A1HSD17B10 | |
| SCHEMBL10504446 | 0.77 | EPAS1 (0.61) | EPAS1MAPTKDM4EALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316478-B1 | IL-8 receptor antagonists | SMITHKLINE BEECHAM CORPORATION | 2001-11-13 | — | — | US | disclosed |